Objective Disruption of hormonal signalling in fetal life can irreversibly affect human development and reproductive health at a later age. Of considerable concern in Europe is a decline in male semen quality and a high prevalence of congenital malformations and hormone-dependent cancers. Although it appears plausible that environmental chemicals with endocrine activity may be involved in the causation of these disorders, there is no evidence for adverse effects of individual substances at relevant human exposure levels. However, there are indications that combinations of chemicals play a cumulative role. CONTAMED aims to explore the hypothesis that combined exposure to endocrine disrupting chemicals in fetal life may lead to adverse delayed impacts on human reproductive health. To achieve this goal, CONTAMED will combine epidemiological approaches with laboratory science. The work plan for CONTAMED is organised in three major strands focusing on human studies, animal models and in vitro assays including metabolomics. The project will deliver new epidemiological insights into associations between cumulative exposure and reproductive health, improved toxicological risk assessment for the anticipation of reproductive effects of chemicals, validated biomarkers for cumulative exposures and new mechanistic information about the ways in which chemicals may disrupt sexual differentiation during development. CONTAMED will provide the knowledge necessary to set the scene for Europe-wide human health impact studies of cumulative exposures to endocrine active chemicals and their possible role in the deterioration of reproductive health in Europe. Finally, the project will analyze the implications of new scientific findings for the European Environment and Health Action Plan and the Community Strategy for Endocrine Disrupters. Fields of science medical and health scienceshealth sciencessocial biomedical sciencessexual healthmedical and health sciencesclinical medicineoncologynatural sciencesearth and related environmental sciencesenvironmental sciencespollution Keywords cumulative exposure human reproductive health Programme(s) FP7-ENVIRONMENT - Specific Programme "Cooperation": Environment (including Climate Change) Topic(s) ENV.2007.1.2.1.2. - Environmental factors and their impact on reproduction and development Call for proposal FP7-ENV-2007-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator BRUNEL UNIVERSITY LONDON EU contribution € 323 304,59 Address KINGSTON LANE UB8 3PH Uxbridge United Kingdom See on map Region London Outer London — West and North West Harrow and Hillingdon Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Kortenkamp (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 603 129,20 Address ANKER ENGELUNDS VEJ 101 2800 Kongens Lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Ulla Hass (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF SUSSEX United Kingdom EU contribution € 499 990,80 Address SUSSEX HOUSE FALMER BN1 9RH Brighton See on map Region South East (England) Surrey, East and West Sussex Brighton and Hove Activity type Higher or Secondary Education Establishments Administrative Contact Elizabeth Hill (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSIDAD DE GRANADA Spain EU contribution € 399 072,80 Address CUESTA DEL HOSPICIO SN 18071 Granada See on map Region Sur Andalucía Granada Activity type Higher or Secondary Education Establishments Administrative Contact Nicolas Olea Serrano (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 323 060,40 Address DR MOLEWATERPLEIN 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Alex Burdorf (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GREEN TOX GMBH Switzerland EU contribution € 499 814,00 Address LANGACKERSTRASSE 49 8057 Zurich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Walter Lichtensteiger (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FAUST UND BACKHAUS ENVIRONMENTAL CONSULTING GBR Germany EU contribution € 150 000,00 Address FAHRENHEITSTRASSE 1 28359 BREMEN See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Faust (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF BRISTOL United Kingdom EU contribution € 290 734,80 Address BEACON HOUSE QUEENS ROAD BS8 1QU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Higher or Secondary Education Establishments Administrative Contact Vince Boyle (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE SCHOOL OF PHARMACY, UNIVERSITY OF LONDON Participation ended United Kingdom EU contribution € 405 245,41 Address Brunswick Square 29-39 WC1N 1AX LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Kortenkamp (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data